Related Products of 446292-08-6, The chemical industry reduces the impact on the environment during synthesis 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, I believe this compound will play a more active role in future production and life.
Into a 100ml three-neck round bottom flask was added the compound (III) (3.0g, 7.1mmol), 25% aqueous methylamine solution (3.89 g of the) and ethanol (22.5ml), heated to 60 ~ 70 for 2 to 3 hours, cooling to room temperature, concentrated hydrochloric acid was added to adjust PH 1-2, filtered, Suntory rivaroxaban V intermediate compound hydrochloride salt 1.98g, yield 85%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Changzhou Nan Fang Pharmaceutical Co., Ltd.; Zhang, Xini; Zi, Chunpeng; Wang, Yingqi; (7 pag.)CN105777734; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem