Reference of 150560-58-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 150560-58-0, name is 5-Isopropylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 11A 6-Isopropyl-3-methyl-2-phenylquinoline-4-carboxylic acid (0396) (0397) 2.50 g (13.21 mmol) of 74 5-isopropyl-1H-indole-2,3-dione were initially charged together with 36 ml of 41 acetic acid and 1.77 g (13.21 mmol) of 40 1-phenylpropan-1-one, and the reaction mixture was stirred at 75 C. for 5 min. Then 12 ml of 42 conc. hydrochloric acid were added, and stirring of the mixture was continued at 105 C. overnight. After cooling to RT, the reaction mixture was added to 500 ml of 1 M hydrochloric acid and the precipitated solids were filtered off. The solids were washed with water and dried under reduced pressure. 2.04 g (31% of theory, 62% purity) of the 75 title compound were obtained. (0398) LC/MS (Method 1, ESIpos): Rt=0.66 min, m/z=306 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Isopropylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bayer Pharma Aktiengesekkschaft; BECK, Hartmut; THALER, Tobias; KAST, Raimund; MEIBOM, Daniel; MEININGHAUS, Mark; TERJUNG, Carsten; DELBECK, Martina; LUSTIG, Klemens; MUENSTER, Uwe; OLENIK, Britta; (100 pag.)US2017/260140; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem