Adding a certain compound to certain chemical reactions, such as: 7699-18-5, name is 5-Methoxyindolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7699-18-5, Safety of 5-Methoxyindolin-2-one
General procedure: 4.4.6 (Z)-3-((2-(3-fluorophenyl)-1H-benzo[d]imidazol-6-yl)methylene)-5-methoxyindolin-2-one (5f) Compound 5f was prepared according to the method described for compound 5a, employing aldehyde 11b (120 mg, 0.5 mmol) and 5-methoxyindolin-2-one (12b, 111 mg, 0.83 mmol) to obtain the pure product 5f as a yellow solid (109 mg, 57%); mp: 196-198 C; IR (KBr): 3424, 3167, 2359, 2340, 1697, 1608, 1452, 1414, 1231, 1207, 1020, 840, 746 cm-1; 1H NMR (300 MHz, DMSO-d6): delta 10.43 (bs, 1H), 8.29-8.22 (m, 2H), 7.99 (s, 1H), 7.79 (s, 1H), 7.76 (d, J = 8.4 Hz, 1H), 7.62 (d, J = 8.3 Hz, 1H), 7.44 (t, J = 8.8 Hz, 2H), 7.32 (d, J = 1.5 Hz, 1H), 6.89-6.72 (m, 2H), 3.62 (s, 3H); 13C NMR (75 MHz, DMSO-d6): delta 168.8, 164.9 and 161.6 (d, J = 248.4 Hz), 153.8, 152.0, 137.4, 136.4, 129.0 (d, J = 8.2 Hz), 128.3, 126.5, 125.9, 124.3, 121.9, 116.0 (d, J = 22.0 Hz), 14.6, 110.2, 108.6, 55.2; MS (ESI): m/z 386 [M + H]+; HRMS (ESI): calcd for C22H17O2N3F m/z 386.12946 [M + H]+; found 386.12993.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methoxyindolin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kamal, Ahmed; Nagaseshadri; Nayak, V. Lakshma; Srinivasulu, Vunnam; Sathish, Manda; Kapure, Jeevak Sopanrao; Suresh Reddy; Bioorganic Chemistry; vol. 63; (2015); p. 72 – 84;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem