In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 200049-46-3, name is 7-Bromo-2,3-dihydro-isoindol-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H6BrNO
7-Bromo-2,3-dihydro-1H-isoindol-1-one (10 g, 47.16 mmol) was added to concentrated H2SO4 (80 mL) at 0 C. and the resulting solution stirred at 0 C. for 0.5 h. N-Iodosuccinimide (15.92 g, 70.74 mmol) was then added and the reaction mixture stirred at 0 C. for 2 h. The reaction mixture was poured on to ice and a precipitate collected by filtration. The solid collected was washed with sat. aq. sodium sulfite (200 ml), water (200 ml) and dried under vacuum to afford crude product as a brown solid. The crude product was triturated with MeOH and the solid obtained dried under vacuum to afford 7-bromo-6-iodo-2,3-dihydro-1H-isoindol-1-one (4.3 g, 27%) as white solid; 1H NMR (400 MHz, DMSO, 30 C.) 4.27 (2H, s), 7.37 (1H, d), 8.11 (1H, d), 8.74 (1H, s); m/z: ES+ [M+H]+=340.
The synthetic route of 200049-46-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem