Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, A new synthetic method of this compound is introduced below., name: 1-(2,6-Dichlorophenyl)-2-indolinone
Example 1Step a) of preparation of sodium diclofenacIn a four-necked glass flask the following ingredients were charged:- 1 -(2,6-dichlorophenyl)-2-indolinone g 592 (M.W. 278.13 moles: 2.128)- Water cc 2368- Sodium hydrosulfite g 40- Sodium hydroxide 30 % g 851 (M.W.: 40; moles: 6.38)The mixture was refluxed for 6 hours, then cooled to 35 – 37 C. The precipitate was filtered on buchner funnel, then washed with water (cc 1600) preheated to 35- 37 C. Wet 1016 grams of sodium diclofenac were obtained corresponding to dry 625 grams (Theor. g 677.1 )
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; COSMA S.P.A.; IBSA INSTITUT BIOCHIMIQUE S.A.; AVOGADRI, Alvaro; LUSSANA, Massimiliano; PIZZATTI, Enrica; BARETTI, Sergio; WO2010/69397; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem