Reference of 172078-33-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 172078-33-0, name is Indolin-5-ol belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 49: 5-Hydroxy-2,3-dihydro-indole-l-carboxylic acid tert-butyl esterA mixture of 2,3-dihydro-lH-indol-5-ol (1.0 g, 7.8 mmol), di-te/t-butyldicarbonate (4.0 g, 18 mmol), chloroform (20 mL) and saturated sodium bicarbonate aq. (8 mL) was stirred at room temperature over night. The organic phase was separated and washed twice with water, dried over MgSO4, filtered and concentrated to give crude product. The crude material was treated with ether and filtered to give product (1.1 g, yield: 60%). ESI-MS: 258.10 (M+23)+, 1H NMR (400 MHz, DMSO) delta 9.00 (s, IH), 7.48 (ws, IH), 6.61 (d, IH), 6.51 (dd, IH), 3.84 (t, 2H), 2.96 (t, 2H), 1.48 (s, 9H).
The synthetic route of Indolin-5-ol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOGEN IDEC MA INC.; THOMAS, Jermaine; LIU, Xiaogao; LIN, Edward, Yin-Shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin, M.; KUMARAVEL, Gnanasambandam; TAVERAS, Arthur, G.; WO2011/17561; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem