These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1074-82-4
To a solution of phtalamide potassium salt (6 g, 32.4 mmol) in DMF (40 mL), was added allyl bromide (2.78 mL, 32.4 mmol). The solution was heated to 7O0C and stirred for 16h. The DMF was removed by rotary evaporation and aqueous extraction was performed with ethyl acetate and water and the organic layer was separated, dried with NaSO4 and concentrated. The residue was purified by silica gel column chromatography with a gradient of ethyl acetate (20-80percent) in hexanes to afford 241 (3.4 g, 57percent) as a white solid.(DMSO-croe) delta(ppm): 7.89 – 7.80 (m, 4H)1 5.90 – 5.80 (m, 1H), 5.12 (t, J=1.6 Hz, 1H), 5.10 -5.06 (m, 1 H), 4.16 (dt, J=5.1 , 1.8 Hz, 2H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1074-82-4.
Reference:
Patent; METHYLGENE INC.; WO2006/102760; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem