In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-(Trifluoromethoxy)indoline-2,3-dione
Weigh 5-trifluoromethoxyBlush1.0g (0.0043mol),5-chloroindole anhydride 0.9g (0.0045mol) was added to a 100ml three-necked flask containing magnetons.Then add 40 ml of chloroform to the three-necked flask.1.5 ml of triethylamine, heated to reflux in an oil bath at 80 C for 3 h,After the reaction is over, stop heating and wait for cooling.The crude product was obtained as a yellow solid powder by suction filtration.The product was washed 3 times with 10 ml of ethanol.Obtaining a pure product yellow solid powder,drying,Weighing 1.12g,The yield was 70.9%.
The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Northwest University; Wang Cuiling; Bai Xiao; Zhang Xiaobin; Liu Jianli; (16 pag.)CN110143964; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem