Reference of 317-20-4,Some common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, molecular formula is C8H4FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(E) -N-Benzyl-2-nitro-N- (p-tolyl) ethane- 1,1-diamine (1 milliliter(1 mmol)) and 7-fluoroindoline-2,3-dione (1 mmol) were added, toluene (15 ml) and trifluoroacetic acidUnder stirring, the mixture was heated to 110 C and refluxed for 14 hours. TLC monitoring reaction until the point of complete disappearance of raw materials, the reaction solutionExtraction was performed by adding 50 ml of ethyl acetate and 50 ml of saturated sodium chloride aqueous solution, the organic layer was dried over anhydrous Na2SO4,The dried organic phase was concentrated to dryness under reduced pressure, and then 3 ml of acetone and 4 g of 100-200 mesh siliconStir the plastic, vacuum evaporated to dryness, the sample was separated with a petroleum ether / ethyl acetate = 7: 1 eluent silica gel column dried to obtain redN-Benzyl-8-fluoro-3-nitro-2- (p-tolylamino) quinoline-4-carboxamide (Compound 40) was obtained in 65% yield.
The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yunnan University; Yan Shengjiao; Wang Baoqu; Lin Jun; (25 pag.)CN107522659; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem