Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 239463-85-5, name is (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate, A new synthetic method of this compound is introduced below., Computed Properties of C26H31N3O8
Step S301: In a 500 mL three-necked bottle, respectively add 5.14 g of 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro -7-cyano-1H-indole tartrate, 150mL dichloromethane, 5mL triethylamine, and stir;After stirring and dissolving, 2.18 g of di-tert-butyl dicarbonate was added in portions, and the reaction was stirred at room temperature for 2 h to obtain a reaction solution;Add 100 mL of purified water to the above reaction solution, stir for 10 min, then stand still for layering;Wash the separated organic phase with 100 mL of purified water and 100 mL of saturated sodium chloride, and then dry the organic phase with anhydrous sodium sulfate for 2 h, and then filter to obtain a filtrate;The filtrate was concentrated under reduced pressure to obtain 3.92 g of light yellow oily compound II, which was 5-[(2R)-2-(tert-butoxycarbonyl)aminopropyl]-1-[3-(benzoyloxy ) Propyl]-2,3-dihydro-7-cyano-1H-indole, the yield of which is 84.48%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Beijing Xinkaiyuan Pharmaceutical Technology Co., Ltd.; Chai Guoju; Zhang Ding; Wu Yanpeng; Li Jing; Ge Zhimin; Dai Xinmin; (17 pag.)CN111116448; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem