Application of 2913-97-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2913-97-5, name is N-(2-Oxoethyl)phthalimide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 2-(1, 3-dioxoisoindolin-2-yl) acetaldehyde (4.0 g, 21.15 mmol) in ethanol (40 mL) added hydroxylamine. HC1 (2.930 g, 42.305 mmol), followed by sodium bicarbonate (3.55 g, 42.305 mmol) at room temperature and stirred at roomtemperature for 16 h. Evaporated off the solvent, added water (50 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic layer was washed with water (100 mL), followed by brine , dried over sodium sulfate and concentrated under vaccue to give the titled compound (3.2 g, 74percent) as off white solid. LCMS: m/z 204.1 [M+H] ?H NMR (300 MHz, DMSO-d6) 11.36 (s, 1H), 7.98?7.78 (m, 4H), 6.83 (t, J= 3.8 Hz,1H), 4.39 (dd, J= 3.9, 0.9 Hz, 2H).
The synthetic route of N-(2-Oxoethyl)phthalimide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; CHIKKANNA, Dinesh; KHAIRNAR, Vinayak; PANIGRAHI, Sunil Kumar; WO2014/111871; (2014); A1;,
Indoline – Wikipedia,
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