Synthetic Route of 20876-36-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20876-36-2, name is 5-Aminoindolin-2-one, This compound has unique chemical properties. The synthetic route is as follows.
Part 1: tert-Butyl 2-oxo-2,3-dihydro-1H-indol-5-ylcarbamate (21): To a mixture of 5-amino-1,3-dihydro-2H-indol-2-one (148 mg, 11.0 mmol), di-tert-butyl dicarbonate (262 mg, 1.2 mmol), and Et3N (279 muL, 2.0 mmol) was added dry THF (5 mL). The suspension was then stirred at rt for 24 h. The reaction was concentrated in vacuo to yield tert-butyl 2-oxo-2,3-dihydro-1H-indol-5-ylcarbamate as a brown solid. 1H NMR (CDCl3, 400 MHz): delta 1.52 (s, 9H), 3.52 (s, 2H), 6.38 (brs, 1H), 6.76 (d, J=8.0 Hz, 1H), 7.07 (dd, J=2.4, 8.4 Hz, 1H), 7.26 (d, J=2.4 Hz, 1H), 7.42 (brs, 1H). MS (ES+): m/z 249 [M+1].
The chemical industry reduces the impact on the environment during synthesis 5-Aminoindolin-2-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Li, An-Hu; Dong, Hanqing; Zhang, Tao; US2006/63791; (2006); A1;,
Indoline – Wikipedia,
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