Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84575-27-9, name is 7-Methoxyindoline-2,3-dione, A new synthetic method of this compound is introduced below., Product Details of 84575-27-9
To a stirring suspension of 7-methoxyindoline-2,3-dione (11 g, 64 mmol) in water (64 ml) was added potassium hydroxide (5.5 g, 80 mmol). The reaction mixture was stirred at 40C for 5h. The reaction mixure was allowed to cool to room temperature, the precipitate was removed through filtration and the filtrate lyophilized to give the title compound as a white solid. The product was used without purification in the next step. LC/MS = 196 [M+1].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ALI, Amjad; ZHOU, Gang; KUANG, Rongze; LIM, Yeon-Hee; LO, Michael Man-Chu; TING, Pauline, C.; BIJU, Purakkattle; RUIZ, Manuel de Lera; DEGRADO, Sylvia, J.; TUNG, Alexander, L.; HENDERSON, Timothy, J.; HONG, Liwu; KIM, Jae-Hun; KIM, David Won-Shik; LEE, Joe, F.; WU, Jie; WU, Heping; XIAO, Yushi; YU, Tao; ZHU, Xiaohong; MCCORMICK, Kevin, D.; TAGAT, Jayaram, R.; XIAO, Dong; KHAN, Tanweer; CAO, Jianhua; BERLIN, Michael; ZHANG, Yonglian; (80 pag.)WO2016/126570; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem