Related Products of 6941-75-9,Some common heterocyclic compound, 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, molecular formula is C8H4BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 5-bromo-1 H-isoindole-1 ,3(2H)-dione (ABCR, 5.Og) and triphenylphosphine (8.7Og) in tetrahydrofuran (THF) (10OmL) under nitrogen at room temperature was added di-t-butyl azodicarboxylate (7.64g). The suspension was cooled in an ice/water bath and to this was added iso-propanol (2.032 ml_). The reaction mixture was allowed to warm to room temperature to give a pale yellow solution. After 60 minutes, the solvent was removed in vacuo and the residue was dissolved in DCM (3OmL). This was applied to a 75Og silica cartridge and eluted with a gradient of 0-40% ethyl acetate in cyclohexane over 8CV. The required fractions were combined and evaporated in vacuo to give the title compound (5.27g) as a pale yellow solid.1H NMR (CDCI3): 7.95 (1 H, d, J=1.5Hz), 7.84 (1 H, dd, J=1.5, 8Hz), 7.68 (1 H, d, J=8Hz), 4.53 (1 H, heptet, J=7Hz), 1.49 (6H, d, J=7Hz)
The synthetic route of 6941-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; JIN, Qi; WO2010/102968; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem