222036-66-0, These common heterocyclic compound, 222036-66-0, name is 5-Aminoisoindolin-1-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-aminoisoindolin-1-one (444 mg, 3 mmol) in 15 mL pyridine was added methylsulfonyl chloride (378 mg, 3.3 mmol), and stirred at room temperature for 4 hours. After the evaporation of the solvent, 1-oxo-5-methylsulfonamidoisoindoline (610 mg) was obtained by silica gel column chromatography. Yield: 90percent. MS m / z [ESI]: 227.0 [M + 1].
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 222036-66-0.
Reference:
Patent; Centaurus BioPharma Co., Ltd.; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XU, Xinhe; SHEN, Yu; XIAO, Dengming; LUO, Hong; PENG, Yong; HAN, Yongxin; ZHANG, Aiming; YANG, Ling; (51 pag.)EP3257857; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem