Adding a certain compound to certain chemical reactions, such as: 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5332-26-3, Recommanded Product: 5332-26-3
To a solution of N-(bromomethyl)phthalimide (2.0 g, 8.3 mmol) in CH2Cl2 (15 mL) was added sodium azide (1.62 g, 24.9 mmol), tetrabutylammonium iodide (0.10 g, 0.33 mmol) and H2O (3 mL). The reaction mixture was heated at reflux for 24 h. The mixture was cooled at room temperature, CH2Cl2 (5 mL) was added and the organic phase was washed and dried over Na2SO4, the solvent was removed in vacuo and the product was purified by crystallisation to afford a yellow solid (1.6 g, 95%); m.p. 39-40 C (lit. 37-39 C);21 FTIR (ATR, cm-1): 3474, 2962, 2872, 2129, 1776, 1712, 1610; 1H NMR (300 MHz, CDCl3) delta 7.94 (dd, J = 5.5, 3.1 Hz, 2H), 7.80 (dd, J = 5.5, 3.1 Hz, 2H), 5.08 (s, 2H); 13C NMR (75 MHz, CDCl3) delta 167.1 (2 ¡Á C), 134.6 (2 ¡Á CH), 131.7 (2 ¡Á C), 123.9 (2 ¡Á CH), 52.2 (CH2); MS [EI+] m/z (%): 202 [M]+ (5), 173 [M – HN2]+ (10), 161 [C8H5N2O2] (10), 159 [M – HN3]+ (40), 147 [C8H5NO2] (10), 133 [C8H5O2] (60), 104 [C7H4O] (100).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Bromomethyl)isoindoline-1,3-dione, and friends who are interested can also refer to it.
Reference:
Article; Lopez-Gonzalez, Ricardo; Bautista-Renedo, Joanatan; Martinez-Otero, Diego; Reyes, Horacio; Gonzalez-Rivas, Nelly; Cuevas-Yanez, Erick; Journal of Chemical Research; vol. 40; 5; (2016); p. 308 – 313;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem