Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16800-68-3, name is 1-Acetylindolin-3-one, A new synthetic method of this compound is introduced below., Computed Properties of C10H9NO2
The N- acetyl-3-indolyl-one 1.75g (10mmol), N- methyl-5-bromo – indole 2.08g (10mmol) and copper triflate 0.18g (0.5mmol) was dissolved in 1, 1,2-dichloroethane, heated to 120 degrees C, the reaction after 16 hours, extracted with methylene chloride, the organic layers combined, dried over anhydrous sodium sulfate, methylene chloride / methanol to give a white solid product N- acetyl-3 – (of N- -3-methyl-5-bromoindole) – indole 3.37g, yield 92%
The synthetic route of 16800-68-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sun Yat-sen University; Weng, Jiang; Lu, Gui; Guo, Jing; (7 pag.)CN105669516; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem