Reference of 14192-26-8, These common heterocyclic compound, 14192-26-8, name is Methyl 2-oxoindoline-6-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A stirred solution of methyl 2-oxoindoline-6-carboxylate (D1) (2.0 g, 10.47 mmol) in acetic anhydride (16 ml) was heated to 130 C under inert atmosphere for 6 h. After complete consumption of the starting material (monitored by TLC), the reaction mixture was cooled to approximately 21 C. The precipitate was filtered, washed with n-hexane (2 x 50 ml) and dried in vacuo to afford compound D2 as a yellow solid (1.5 g, 61.5%).1H NMR (400 MHz, DMSO -de)6 8.66 (s, 1 H), 7.82 (d, J = 8.0 Hz, 1 H), 7.48 (d, J = 8.0 Hz, 1 H), 3.91 (s, 2H), 3.87 (s, 3H), 2.57 (s, 3H)
The synthetic route of 14192-26-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNTHIS, LLC; THOMAS-KARYAT, Dori A.; (0 pag.)WO2020/13803; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem