Reference of 2058-74-4, These common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Sulfonated-b-cyclodextrin (b-CD-SO3H) (0.1 mmol) was dissolved in water(2 mL) at room temperature by stirring to get the clear solution. Then thereaction was shifted to reflux with addition of isatin (1 mmol) and indole(2 mmol) with constant stirring. The progress of the reaction was monitored byTLC. After completion of reaction, it was cooled to room temperature andfiltered, to get the solid. The crude product was recrystallized from aqueousethanol (60:40) giving pure 3,3-di(indolyl)indolin-2-ones.
The synthetic route of 2058-74-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tayade, Yogesh A.; Patil, Dipak R.; Wagh, Yogesh B.; Jangle, Asha D.; Dalal, Dipak S.; Tetrahedron Letters; vol. 56; 5; (2015); p. 666 – 673;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem