Application of 15362-40-0,Some common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, molecular formula is C14H9Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a four-necked flask was added compound IV (233 g, 0.84 mol), potassium hydroxide (94.3 g, 1.68 mol), 10% hydrochloric acid 668 mL, zinc hydroxide (167 g, 1.68 mol), and the temperature was raised to 85 C for 8 hours , Cooling to 60 ~ 65 , vacuum filtration, filter cake and add a small amount of water to get 499.5g (compound I: diclofenac zinc), the yield of 91%.
The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jilin University; Liaoyuan Yinying Pharmaceutical Co., Ltd.; Li Guiying; Wang Zhaokun; Li Shumei; Peng Xiaojuan; Jin Xingtong; (8 pag.)CN106905178; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem