Application of 611-09-6,Some common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, molecular formula is C8H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 2 (200mg, 1.04mmol), neopentyl glycol (108mg,1.04mmol) and p-toluenesulfonic acid (25mg, 145mumol) were suc-cessively added and dissolved in cyclohexane (10mL). The resulting reaction mixture was refluxed for 16 h at 85 C. After completion of the reaction, the mixture was cooled to room temperature. Then, the pre-cipitate was filtered ,washed with water and dried .Purification by chromatography on silica gel (petroleum ether/ethyl acetate=5/1)afforde dintermediate3.White solid; yield 84%; mp: 201-203C; 1 H NMR (400MHz,DMSO-d 6 ) delta 11.20 (s, 1H), 8.28 (dd, J=8.7, 2.4Hz, 1H), 8.08 (d,J=2.4Hz, 1H), 7.04 (d, J=8.7Hz, 1H), 4.49 (d, J=11.0Hz, 2H),3.55 (d, J=11.2Hz, 2H), 1.34 (s, 3H), 0.84 (s, 3H).
The synthetic route of 611-09-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yu, Shengping; Liu, Yang; Zhang, Zhen; Zhang, Jingya; Zhao, Guisen; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3319 – 3327;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem