Demont, Emmanuel H. published the artcileFragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors, Product Details of C10H12BNO3, the publication is Journal of Medicinal Chemistry (2015), 58(14), 5649-5673, database is CAplus and MEDLINE.
Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependence of these effects upon the ATAD2 bromodomain, which has been categorized as among the least tractable of its class. The absence of any potent, selective inhibitors limits clear understanding of the therapeutic potential of the bromodomain. Here, the authors describe the discovery of a hit from a fragment-based targeted array. Optimization of this produced the first known micromolar inhibitors of the ATAD2 bromodomain, e.g. I.
Journal of Medicinal Chemistry published new progress about 905971-97-3. 905971-97-3 belongs to indolines-derivatives, auxiliary class Boronic acid and ester,Boronic Acids, name is (1-Acetylindolin-5-yl)boronic acid, and the molecular formula is C10H12BNO3, Product Details of C10H12BNO3.
Referemce:
https://en.wikipedia.org/wiki/Indoline,
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