Safety of Indolin-2-one. Recently I am researching about SECONDARY AMIDES; N-ALKYLATION; CHEMOSELECTIVE REDUCTION; TERTIARY AMIDES; ACID; DERIVATIVES; CHEMISTRY; NITRILES; ESTERS; CARBON, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372258]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Research Funds of Renmin University of China [16XNLQ04]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Pan, YX; Luo, ZL; Xu, X; Zhao, HQ; Han, JH; Xu, LJ; Fan, QH; Xiao, JL. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one
A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)(2)(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway.
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Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem