Recently I am researching about TOBACCO-MOSAIC-VIRUS; LULICONAZOLE; BIOACTIVITY; MECHANISMS; DESIGN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21867002]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one. Formula: C8H7NO
Thirty unreported indole derivatives containing dithioacetal moiety were synthesized and evaluated for antiplant viral activity. Bioassay results displayed that some of the target compounds showed better activities against tobacco mosaic virus (TMV) than the commercial Ribavirin in vivo. In particular, anti-TMV curative, protective and inactivating activity of 4p were 55.1, 57.2, and 80.3%, respectively, and EC50 value for inactivating activity was 88.5 mu g/mL. The observation of transmission electron microscope showed that 4p may have a certain destructive effect on TMV particles. To further study, microscale thermophoresis analysis result also demonstrated that 4p powerfully interacted with TMV coat protein in vitro. Hence, this study provides a strong evidence suporting that indole derivatives might be applied as new antiviral agents.
Formula: C8H7NO. About Indolin-2-one, If you have any questions, you can contact Wei, CL; Zhao, L; Sun, ZR; Hu, DY; Song, BA or concate me.
Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem