I found the field of Chemistry very interesting. Saw the article Ru-Catalyzed Deoxygenative Transfer Hydrogenation of Amides to Amines with Formic acid/Triethylamine published in 2019. Safety of Indolin-2-one, Reprint Addresses Xu, LJ (corresponding author), Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.; Fan, QH (corresponding author), Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China.; Xiao, JL (corresponding author), Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England.. The CAS is 59-48-3. Through research, I have a further understanding and discovery of Indolin-2-one
A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)(2)(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway.
Safety of Indolin-2-one. About Indolin-2-one, If you have any questions, you can contact Pan, YX; Luo, ZL; Xu, X; Zhao, HQ; Han, JH; Xu, LJ; Fan, QH; Xiao, JL or concate me.
Reference:
Indoline – Wikipedia,
,Indoline | C8H9N – PubChem