Related Products of 169037-23-4, The prevalence of solvent effects in heterogeneous catalysis has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states.
General procedure: General method: The Schiff bases were obtained by adding an ethanolic solution of the hydrazinyl component to the solution of the keto component in equimolar amounts, refluxing the mixture in the presence of catalytic amounts of acid. If not indicated otherwise, purification was carried out by recrystallization. Carbazides were prepared by adding an equimolar amount of hydrazine to the methanolic solution of the respective isothiocyanate [53]. For the picolinylidene derivatives with ethyl group in 5-position of the pyridine moiety (2e, 2k), 5-Ethylpicolinaldehyde was prepared from 5-ethyl-2-methyl-pyridine as reported previously [13,115]. The reaction of 5-trifluoromethoxyisatin (50mg, 0.22mmol) with N-(4-methoxyphenyl)hydrazinecarbothioamide C-1 (43mg, 0.22mmol) in ethanolic solution under HCl-catalysis resulted in a yellow fluffy precipitate, which was identified as the product in 70% yield (65.7mg, 0.16mmol). 1H NMR (500MHz, DMSO-d6): delta=12.60 (s, 1H), 11.36 (s, 1H), 10.78 (s, 1H), 7.78 (s, 1H), 7.49-7.41 (m, 2H), 7.41-7.31 (m, 1H), 7.02 (d, 1H, 3J(H,H)=5.0Hz), 7.01-6.95 (m, 2H), 3.78 (s, 3H). 13C NMR (126MHz, DMSO-d6): delta=176.6, 162.7, 157.5, 143.5, 141.2, 131.1, 130.9, 127.3 (2C), 124.0, 121.5, 120.7 (d {121.19, 119.15}, 1J(C,F)=255.7Hz), 114.4 (2C), 113.6, 112.1, 55.3. Anal. Calcd. for C17H13N4SO3F3: C: 49.76; H: 3.19; N: 13.65. Found: C: 49.61; H: 3.477; N: 13.53
According to the analysis of related databases, 169037-23-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pape, Veronika F.S.; Toth, Szilard; Fueredi, Andras; Szebenyi, Kornelia; Lovrics, Anna; Szabo, Pal; Wiese, Michael; Szakacs, Gergely; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 335 – 354;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem