Quality Control of 4-Hydroxy-2,3-dihydroisoindol-1-one, The chemical industry reduces the impact on the environment during synthesis 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, I believe this compound will play a more active role in future production and life.
A solution of DEAD (250 muL, 1.59 mmol) in THF (1 mL) was added dropwise to a solution of 1 h (50.6 mg, 0.17 mmol), Ph3P (54.5 mg, 0.21 mmol) and phenol 2d (24.9 mg, 0.17 mmol) in THF (1.8 mL) at room temperature. After 16 h, the mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (EtOAc/EtOH, 92/8) to give compound 101 (20 mg, 28% yield) as a white solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Hydroxy-2,3-dihydroisoindol-1-one.
Reference:
Patent; Boehringer Ingelheim (Canada) Ltd.; US2004/106791; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem