With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing., Application of 5332-26-3
N-(Bromomethyl)-phthalimide (14.4 g, 0.06 mol) and triethyl phosphite (12.0 g, 0.072 mol) were placed in a round-bottomed flask equipped with a reflux condenser and heated at 85-100 C. for 30 min. After the exothermic reaction had subsided, the flask was fitted for simple distillation and ethyl bromide was distilled from the reaction mixture with heating at 100-110 C. for 2 hours. The resulting light yellow oil solidified at room temperature. The crude product was washed with hexane and recrystallized from diethyl ether/hexane to yield white crystals. 16.0 g, 89.9%; mp 66-67 C. (lit. 67 C.); 1H NMR (CDCl3) delta 7.76 (m, 4H, C6H4), 4.19 (q, 4H, OCH2), 4.17 (d, 2H, CH2P), 1.33 (t, 6H, CH3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Bromomethyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; Board of Regents the University of Texas System; US6746662; (2004); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem