Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. Computed Properties of C8H4FNO2
To a mixture of 5.0 g (30.3 mmol) 6-fluoro-1H-indole-2,3-dione in 75 mL of 33% aq. potassium hydroxide solution was added 4.67 g (53.0 mmol) pyruvic acid and this mixture was heated at 40C for 18 hours. After cooling to room temperature 10% aq. sulfuric acid was added (pH about 1). The formed solid was isolated by filtration and dried in vacuum. The solid was the desired 7-fluoroquinoline-2,4-dicarboxylic acid,which was used without further purification. Yield: 6.02 g (85%).1H-NMR (300 MHz, DMSO d6) 6 (ppm) = 7.78 (ddd, 1H), 7.99 (dd, 1H), 8.42 (s, 1H),8.89 (dd, 1H).
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; BUCHMANN, Bernd; CLEVE, Arwed; HEROULT, Melanie; NEUHAUS, Roland; PETRUL, Heike; QUANZ-SCHOeFFEL, Maria; KOPITZ, Charlotte Christine; (285 pag.)WO2016/202935; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem