In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Product Details of 1127-59-9
General procedure: Compound B (11.9 mg, 0.02 mmol) was added at 4 C in a mixed solution of Eosin 1a (29.4 mg, 0.2 mmol) and methyl acetoacetate 2a (107.8 muL, 1.0 mmol) in tetrahydrofuran (1.0 mL). The reaction was stirred at 4 C for 96 hours. Spin-drying, column chromatography (petrole ether: ethyl acetate = 1 : 1-1 : 2), and evaporated to give a pale yellow amorphous solid 49.0mg, yield 93%, 90% ee.
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Reference:
Patent; Anhui University of Technology; Zhang Dongxin; Yin Lei; Zhong Junchao; Man Jingjing; Chen Yan; Zhang Qianfeng; (21 pag.)CN110041243; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem