In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C22H19N3O6
210.7 g (0.5 mol) of (S)-2-{[2-oxo-3-(4-(3-oxomorpholine)phenyl]oxazolidine-5-yl] prepared in Example 7 was added to the reaction flask. Methyl isonon-1,3-dione (formula VII), 1500 ml of anhydrous ethanol, and 500 ml of a 30% aqueous solution of methylamine were stirred well.The reaction was heated to 40C to 60C for 8 hours, and TLC control (dichloromethane:methanol = 20:1, volume ratio) was completed.Adjust pH to 1-2 with 10% hydrochloric acid.A large amount of white solids precipitated and cooled to about 15C.Stir for 2 hours, filter and filter cake washed with 300 ml absolute ethanol.Drying under reduced pressure gave 147.0 g of a white solid (formula VIII) in a molar yield of 89.7%. The HPLC purity was 98.7%.
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Reference:
Patent; Peking University Fangzheng Group Co., Ltd.; Peking University Pharmaceutical Co., Ltd.; Peking University Medical Treatment Industrial Group Co., Ltd.; Xu Hong; Tian Juan; Zhang Zheng; Wang Wei; Ren Juan; (16 pag.)CN105085508; (2017); B;,
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