In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Application In Synthesis of 5,7-Dimethylindoline-2,3-dione
45. A. SYNTHESIS OF 5, 7-DIFNETHYL-IH-INDOLE To solution of 5, 7-dimethyl-lH-indole-2, 3-dione in tetrahydrofuran at 0 C was added 1. 0 M solution of borane-tetrahydrofuran complex in tetrahydrofuran (40 mL). After stirred at room temperature overnight, a 5% HCl solution was added to the mixture and it was stirred 20 minutes. It was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and evaporated to dryness to afford the title compound as oil.
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Reference:
Patent; SALMEDIX, INC.; WO2005/33112; (2005); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem