In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6344-05-4, name is 4-Chloroisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 6344-05-4
80 kg of 2- [4- (1,3-dioxo-2-isoindolinol] phenylbutyric acid prepared in the method of Example 1 and 480 L of acetic acid were charged into a reaction vessel, and stirring was started. A mixture of 64 kg Zinc powder into the reaction tank, atmospheric pressure into the hydrogen chloride gas,The reaction temperature was controlled at 82 C, the reaction started, the reaction time was 1 hour, the reaction liquid all clear. Filter, wash the residue with acetic acid, The filtrate and washings were combined, the solvent was removed under reduced pressure, the residue was poured into appropriate amount of water, stirred and adjusted to pH 5.5-6.5 by ammonia water, dried and centrifuged to give 72.3 kg of indobufen crude product with a yield of 94.7% and a purity of 98.0%
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 6344-05-4.
Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Cao Dongsheng; Han Tao; Zhou Hanjun; Yu Rui; (8 pag.)CN106631974; (2017); A;,
Indoline – Wikipedia,
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