In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356068-93-4, name is (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 356068-93-4
To a stirred solution of 1 (0.5 g, 1.67 mmol) in DMF( 35 mL) at room temperature was added HOBt(1.02 g, 7.52 mmol), triethylamine (2.12 mL, 15.03 mmol), ECDI HCl(1.44 g, 1.52 mmol) and methyl 3-aminopropanate hydrochloride(0.7 g, 5.0 mmol) successively. The mixture was stirred for 24 h at room temperature and then was diluted with water (20 mL), brine (20 mL) and saturated bicarbonate solution (20 mL) and the pH of solution was adjusted to 11-12 with 10 mol/L NaOH. The mixture was filtrated and the solid was collected washed with water, dried to obtain crude yellow solid product 110-2 (0.44 g, 68.3%). LCMS: m/z 386(M+1), 1H NMR(DMSO-J6) delta2.38 (s, 3H), 2.41 (s, 3H), 2.50 (t, 2H),3.44 ( t, 2H), 3.62 (s,3H), 6.85 (m, 2H), 7.71 (m,3H), 10.86 (s, IH), 13.69 (s, IH).
The synthetic route of 356068-93-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CURIS, INC.; WO2008/33747; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem