Application of 114041-16-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 114041-16-6, name is 5,6-Dimethoxyisoindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Compound 8 (70.6 mg, 0.24 mmol) and 5,6-dimethoxyisoindoline(68.5 mg, 0.38 mmol) were dissolved in CH3CN (30 mL), followed by addition of K2CO3 (138.8 mg, 1.00 mmol). The mixture was heated under reflux and stirred at 90 C for 6 h. After cooling and filtration, the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate/triethyamine) = 10:10:1, v/v/v) to afford 13(56.8 mg, 59%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3): d7.15-7.06 (m, 3H, Ar-H), 6.77 (s, 2H, Ar-H), 6.66 (dd, J = 3.1,0.5 Hz, 1H, Ar-H), 6.52 (d, J = 7.2 Hz, 1H, Ar-H), 4.84 (dt, J = 47.5,4.2 Hz, 2H, F-CH2), 4.37 (dt, J = 27.8, 4.3 Hz, 2H, O-CH2), 4.27 (t,J = 6.7 Hz, 2H, indole N-CH2), 3.87 (s, 10H, O-CH3, Ar-CH2-N), 2.65(t, J = 6.7 Hz, 2H, N-CH2), 2.08-2.05 (m, 2H, CH2). 13C NMR(100 MHz, CDCl3) d (ppm): 152.43, 148.63, 137.94, 131.86,127.08, 122.29, 119.61, 106.14, 103.84, 100.64, 98.63, 82.35(J = 169.2, F-CH2), 67.49 (J = 20.6, O-CH2), 59.32, 56.34, 52.75,44.12, 29.56. ESI-TOF MS calcd for C23H28FN2O3 [M+H]+:399.2084; found: 399.2076.
The synthetic route of 5,6-Dimethoxyisoindoline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Liang; Ye, Jiajun; He, Yingfang; Deuther-Conrad, Winnie; Zhang, Jinming; Zhang, Xiaojun; Cui, Mengchao; Steinbach, Joerg; Huang, Yiyun; Brust, Peter; Jia, Hongmei; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3792 – 3802;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem