Introduction of a new synthetic route about 59-48-3

These common heterocyclic compound, 59-48-3, name is Indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Indolin-2-one

These common heterocyclic compound, 59-48-3, name is Indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Indolin-2-one

To a 50 ml single-flask containing 30 ml of acetonitrile was cooled to 0C. Indole-2-one (0.023 mol) and N-bromosuccinimide (0.023 mol) was added, and then stirred at 0C for 4 hours. The primrose precipitate was collected by vacuum filtration, washed with water, and dried under in the air.

The synthetic route of Indolin-2-one has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Lihong; Li, Zhanshan; Lu, Lianhong; Zhang, Wei; Tetrahedron; vol. 68; 5; (2012); p. 1483 – 1491;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem