Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C22H19N3O6
The reaction flask was charged with 210.7 g (0.5 mol) of the compound prepared in Example 7,(S) -2- {[2-oxo-3- (4- (3-oxorpholine) phenyl) oxazolidin-5-yl] methyl} isoindole- VII),1500ml of anhydrous ethanol, 500ml of 30% aqueous solution of methylamine, stirring evenly,The temperature was raised to 40 C to 60 C for 8 hours,TLC in the control (dichloromethane: methanol = 20: 1, volume ratio) reaction is complete,With 10% hydrochloric acid to adjust the pH to 1-2 between the precipitation of a large number of white solid, cooling to about 15 C,Stirring for 2 hours, filtering, filter cake with 300ml anhydrous ethanol washing, vacuum drying,A mixture of 147.0 g of the white solid (compound of formula VIII) was obtained in a molar yield of 89.7%, and 1 ^ (purity: 98.7%).
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Peking University Fangzheng Group Co., Ltd.; Peking University Pharmaceutical Co., Ltd.; Peking University Medical Treatment Industrial Group Co., Ltd.; Xu Hong; Li Linfeng; Zhang Zheng; Wang Wei; Ren Juan; (15 pag.)CN105085371; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem