Reference of 1127-59-9, These common heterocyclic compound, 1127-59-9, name is 7-Methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 0.31 g (1.1 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl acetate 14 and 0.03 mL of triethyl-amine were added to a continuously stirred solution of the isatin derivative 1?13 (1 mmol) in DMF. The reaction was performed at 70°, completion of the reaction of the reactants was determined by TLC. After cooling to ambient, the reaction mixture was poured into a brine. The obtained precipitate was filtered off, washed with water, and dried in vacuum (12 mmHg).
The synthetic route of 1127-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bogdanov; Zaripova; Voloshina; Strobykina; Kulik; Bukharov; Mironov; Russian Journal of General Chemistry; vol. 88; 1; (2018); p. 57 – 67; Zh. Obshch. Khim.; vol. 88; 1; (2018); p. 61 – 71,11;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem