Electric Literature of 71294-03-6,Some common heterocyclic compound, 71294-03-6, name is 7-Fluoroindolin-2-one, molecular formula is C8H6FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
40 g of 7-fluoroanthraquinone was added to 450 ml of anhydrous methylene chloride, 15 g of aluminum trichloride was added, 60 g of oxalyl chloride was added, the mixture was heated to reflux for 2 hours, cooled to room temperature, and then water was added thereto for liquid separation, drying, and concentration. The residue was columned to give 47 g of 2-(7-fluoro-1H-indol-3-yl)-2-oxoacetyl chloride.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Fluoroindolin-2-one, its application will become more common.
Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Cheng Jia; (6 pag.)CN107698483; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem