In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64483-69-8 as follows. Recommanded Product: 64483-69-8
5-Acetyl-2-oxindole (2 g) in 15 mL trifluoroacetic acid in an ice bath was slowly treated with 1.8 g triethylsilane and then stirred at room temperature for 5 hours. One mL of riethylsilane was added and the stirring continued overnight. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of the title compound as a yellow solid. 1H-NMR (360 MHz, DMSO-d6): delta 10.25 (s, br, NH-1), 7.03 (s, 1 H, H-4), 6.97 (d, J=8.05 Hz, 1 H, H-6), 6.69 (d, J=8.05 Hz, 1 H, H-7), 3.40 (s, 2 H, CH2-3), 2.51 (q, J=7.69 Hz, 2 H, CH2CH3-5), and 1.12 (t, J=7.42 Hz, 3 H, CH2CH3-5).
According to the analysis of related databases, 64483-69-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sugen, Inc.; US6395734; (2002); B1;,
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