Reference of 350797-56-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 350797-56-7 name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: Raw materials (II), hydrochloric acid added to the organic solvent, heated to a certain temperature, slowly adding zinc powder in batch, by thin layer chromatography (TLC) or high performance liquid chromatography (HPLC) to the raw material (II) completely react , The filter cake is washed with a solvent to the product (I), and then subjected to separation and purification by conventional means such as concentration, washing, drying,To give the salt of the compound (I), which is obtained by alkalizing the free base of (I).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, and friends who are interested can also refer to it.
Reference:
Patent; Changzhou Ruiming Pharmaceutical Co., Ltd.; Shi Weiming; (5 pag.)CN106928118; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem