Related Products of 150544-04-0, A common heterocyclic compound, 150544-04-0, name is 6-Aminoindolin-2-one, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of above compound (2 g) and ethyl 1,3-dioxobenzo[c]azolidine-2-carboxylate (1.1 eq) in THF was refluxed overnight. The reaction was cooled and the precipitate was filtered. The gray solid (2 g) was heated with acetic anhydride (2 eq) in acetic acid (40 ml) at 115° C. overnight. The solvent was evaporated and the product was triturated with 50percent EtOAc/Hexane and filtered to give 1-acetyl-6-(1,3-dioxobenzo[c]-azolidin-2-yl)-2-oxoindoline as a dark gray solid.
The synthetic route of 150544-04-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chen, Guoqing P.; US2004/259916; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem