Synthetic Route of 446292-08-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 446292-08-6 as follows.
The reaction flask was charged with 210.7 g (0.5 mol) of the compound prepared in Example 7, (S)-2-{[2-oxo-3-(4-(3-oxorpholine)phenyl)oxazolidin-5-yl]methyl}isoindole-(VII), 1500 ml of absolute ethanol, 500 ml of 30% aqueous methylamine solution, stirred evenly, heated to 40 C to 60 C for 8 hours, TLC in the control (dichloromethane: methanol = 20: 1, volume ratio) reaction is complete, with 10% hydrochloric acid to adjust the pH between 1-2 to precipitate a large number of white solid, cooled to about 15 C, stirring 2 hours, filter. The filter cake was washed with 300 ml of absolute ethanol and dried under reduced pressure to give 147.0 g of a white solid (compound of formula VIII) with a molar yield of 89.7% and an HPLC purity of 98.7%.
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Peking University Fangzheng Group Co., Ltd.; Peking University Pharmaceutical Co., Ltd.; Peking University Medical Treatment Industrial Group Co., Ltd.; Xu Hong; Lei Bingying; Zhang Zheng; Wang Wei; Ren Juan; (15 pag.)CN105085370; (2017); B;,
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