Adding a certain compound to certain chemical reactions, such as: 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3676-85-5, Recommanded Product: 3676-85-5
At room temperature,In a 25mL reaction bottle,Join in order3-aminophthalic acid imide(0.5 mmol), diphenylphosphoryl (1 mmol),TEMPO (0.05 mmol), and tetrahydrofuran 48 mmol, 2 mL), mixed evenly,The reaction is then heated to 40 C.The reaction was stirred for 12 hours.After the reaction was completed by TLC, pure water was added.Then add ethyl acetate for 3 times.The extracts are combined and the extract is dried over anhydrous sodium sulfate.The extract was concentrated under reduced pressure in vacuo (0.08 Mpa) to dryness to afford crude material.Then rinse with a mixed eluent of 3:1 by volume of petroleum ether and ethyl acetate.Silica gel column flash column chromatography,Obtaining the product of Example 4o,It was 152 mg of a yellow solid, yield 70%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Aminoisoindoline-1,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; Qufu Normal University; Wei Wei; Huang Qiang; Lv Yufen; Liu Qishun; (20 pag.)CN109942627; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem