Synthetic Route of 18711-13-2, A common heterocyclic compound, 18711-13-2, name is 4,7-Dichloroindoline-2,3-dione, molecular formula is C8H3Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example II-96 : (2-Oxo-1, 2-dihydro-pyrimidin-5-yl)-acetic acid [(3Z)-4,7-dichloro-2-oxo-1,2- DIHYDRO-INDOL-3-YLIDENE]-HYDRAZIDE [0639] The (at)TURE OF (2-OXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID HYDRAZIDE (67 MG, 0. 4 mmol) and 4,7-dichloro-isatin (95 mg, 0.44 mmol) in AcOH (10 mL) was stirred at 100″C FOR 3 h. After removal of the solvent, the residue was CRYSTALLIZED FROM MEOH TO GIVE THE TITLE compound as yellow solid (45 mg, 31%). [0640] H-NMR (400 MHz, DMSO-d6) 612. 68 (s, 1H), 11.92 (s, 1H), 8.41 (s, 2H), 7.46 (d, 1H), 7.16 (d, 1H), 4.00 (s, 2 H); MS (m/z) 366 [M+1].
The synthetic route of 18711-13-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUGEN, INC.; WO2005/5378; (2005); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem