Electric Literature of 496-12-8, The chemical industry reduces the impact on the environment during synthesis 496-12-8, name is Isoindoline, I believe this compound will play a more active role in future production and life.
Example 13; Synthesis of 4-chloro-6-(1.3-dihvdro-2H-isoindol-2-yl)pyrimidin-2- amine (Intermediate 18); 4,6-Dichloropyrimidin-2-amine (1.12g), isoindoline (1.2ml), and triethylamine (1.63ml) in EtOH (33ml) are heated with stirring at 85 0C for 6 hours. The solvent is removed in vacuo, and the residual solid suspended in DCM (40ml) and dilute citric acid solution (30ml). The suspended solid is filtered off, washed with DCM and water, and dried to afford the title compound as a grey solid (1.573g, 93%). LCMS 247 [M+H]+, RT 3.05 mins (pH 2.5). 1H NMR 300 MHz (CDCI3) (delta ppm): 7.25 – 7.48 (4H, m), 6.58 (2H, s), 5.92(1H, s), 4.71 (4H, br d).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UCB PHARMA, S.A.; WO2008/31556; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem