Synthetic Route of 5428-09-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5428-09-1, name is 2-Allylisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: The optimized hydroformylation?Biginelli reactions were performedby charging an autoclave with [Rh(CO)2acac] (2.60 mg,10.0 mumol 0.25 molpercent), Xantphos (57.9 mg 100 mumol, 2.5 molpercent),and urea (2, 132 mg, 2.2 mmol, 1.1 equiv) as solids under an atmosphereof argon. Subsequently, a solution of the alkene (4 mmol, 2equiv), ethyl acetoacetate (3, 0.25 mL, 260 mg, 2 mmol, 1 equiv)and concd HCl (40 muL) in EtOH (4 mL) was prepared and thentransferred into the autoclave via syringe. The autoclave was purgedthree times with syngas (CO/H2, 1:1), pressurized at 20 bar, andplaced in a preheated aluminum block at 100 °C. The reactions werestopped after 24 h by cooling the autoclave in a water bath (18 °C),venting and purging with argon. To the crude reaction mixture1,3,5-trimethoxybenzene (33.6 mg, 0.20 mmol, 0.1 equiv) as internalstandard was added and the suspension dissolved in CH2Cl2 (5mL). After evaporation of the solvents the crude product was analyzedby NMR spectroscopy and purified via flash chromatographyto yield the pure 3,4-dihydropyrimidin-2(1H)-ones 6a?l as colorlesssolids or foams
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Allylisoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fuchs, Daniela; Nasr-Esfahani, Mahboobeh; Diab, Lisa; Smejkal, Tomas; Breit, Bernhard; Synlett; vol. 24; 13; (2013); p. 1657 – 1662;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem