Application of 480-91-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 480-91-1 name is Isoindolin-1-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
At 0 C., 611.3 mg (15.3 mmol, 60% pure) of sodium hydride were added to 2.035 g (15.3 mmol) of 1-oxoindoline in 12 ml of DMF. The mixture was stirred for 30 min, and 6.0 g (12.7 mmol) of tert-butyl(+/-)-[4-(bromomethyl)phenyl](cyclopentyl)acetate were then added at 0 C. The reaction mixture was stirred for a further 4 h, water was then added and the mixture was extracted twice with dichloromethane. The combined organic phases were washed with saturated sodium chloride solution, dried over magnesium sulfate and concentrated. The crude product was treated with diethyl ether in an ultrasonic bath and the solid was isolated by filtration. This gave 3.40 g (60.2% of theory) of the target compound.LC-MS (method 11): Rt=1.57 min; m/z=350 (M-C4H8+H)+.1H-NMR (400 MHz, DMSO-d6): delta=7.72 (d, 1H), 7.60-7.50 (m, 3H), 7.30 (d, 2H), 7.21 (d, 2H), 4.71 (s, 2H), 4.38 (s, 2H), 3.18 (d, 1H), 2.35 (m, 1H), 1.85-1.37 (m, 5H), 1.34 (s, 9H), 1.20 (m, 2H), 0.91 (m, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Isoindolin-1-one, and friends who are interested can also refer to it.
Reference:
Patent; BAYER SCHERING PHARMA AKTIEGESELLSCHAFT; US2011/34450; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem