Adding a certain compound to certain chemical reactions, such as: 32692-19-6, name is 5-Nitroindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32692-19-6, SDS of cas: 32692-19-6
Reference Example 98To 5-nitroindoline (1.Og, 6. lmmol) in acetone (12ml), powdered potassium hydroxide (1.7g, 30.5mmol, 5eq) was added followed by the addition of methyl iodide (1.2g, 9. lmmol, 1.5eq) at 00C. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated and water was added and the compound was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to dryness to yield l-methyl-5 -nitro-2,3-dihydro-l H-indole (l.Og, 92%). The crude compound was used in the next stage without purification. Reference Example 103 l-Methyl-2,3-dihydro-lH-indol-5-ylamine a) Preparation of l-methyl-5-nitro-2,3-dihydro-lH-indoleTo a solution of 5-nitro-2,3-dihydro-lH-indole (Ig, 6.09mmol) in acetone (12ml) was added powdered potassium hydroxide (1.7g, 30.45mmol), followed by methyl iodide (1.2g, 9.14mmol) and stirred overnight at ambient temperature. The solvent was evaporated under vacuum to give a residue, to which water was added and the product extracted with ethyl acetate. Drying and concentration of the organic layer yielded 1- methyl-5-nitro-2,3-dihydro-lH-indole (Ig, 92%) as solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Nitroindoline, and friends who are interested can also refer to it.
Reference:
Patent; F2G LTD; WO2006/123145; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem