Synthetic Route of 141452-01-9, These common heterocyclic compound, 141452-01-9, name is Methyl indoline-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 17 (0.28 g, 1.58 mmol) in pyridine (2 mL) was added 4-methoxybenzenesulfonyl chloride (0.32 g, 1.58 mmol) and heated to reflux for 6 h. The reaction mixture was purified by chromatography over silica gel to afford 18c as a white solid (85% yield; 1:1 EtOAc/n-hexane): 1H NMR (300 MHz, CDCl3) delta 2.96 (t, J=8.7 Hz, 2H), 3.80 (s, 3H), 3.85 (s, 3H), 3.93 (t, J=8.7 Hz, 2H), 6.89 (d, J=8.7 Hz, 2H), 7.62 (d, J=8.4 Hz, 1H), 7.20-7.76 (m, 3H), 7.88 (d, J=8.4 Hz, 1H).
Statistics shows that Methyl indoline-5-carboxylate is playing an increasingly important role. we look forward to future research findings about 141452-01-9.
Reference:
Patent; Taipei Medical University; Liou, Jing-Ping; Lin, Chien-Huang; Pan, Shiow-Lin; Yang, Chia-Ron; Teng, Che-Ming; US2015/368195; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem